The Protein Folding Problem: Anfinsen hypothesis and Levinthal paradox
Dr. Aditya Arya, Dr. Amit Kumar
Date of publication: 21 Aug 2016
We all know that proteins fold spontaneously on keeping them in suitable aqueous environment. However, there are some deeper questions which we must know about protein folding that, what are the models of proteins folding? Which route does a protein follow while folding? And how protein folding does not defy the second law of thermodynamics despite of the fact the randomness of protein itself is reduced on folding? We would also understand two famous hypothesis put forth by Levinthal and Anfinsen and various probability based question arising about the protein structure. . Infact the work of Anfinsen was recognized globally and he was awarded Nobel Prize in chemistry in the year 1972. Finally this note will end with a few practice MCQs based on the two key concepts.
There have been a number of questions in MSc entrances including JNU, IISc and TIFR on anfinsen hypothesis and levinthal paradox.